PL-1 Christopher M. Overall
Professor Overall started his UBC lab in 1993 after a MRC Centennial Fellowship with Dr. Michael Smith, Nobel Laureate (1989-), with subsequent pharmaceutical experience at British Biotech, Oxford (1997-1998) and Novartis, Basel (2004/2008). He is a Tier 1 Canada Research Chair in Protease Proteomics, Life Sciences Institute with cross-appointments/affiliations with the Center for Blood Research, Department Biochemistry/Molecular Biology, and is an Honorary Professor, Albert-Ludwigs Universität Freiburg.
As recognized by the 2017 HUPO Discovery Award in Proteomics Sciences, he is best known for two related but distinct scientific achievements. The first is development of new proteomic methods for discovery of protein substrates of proteolytic enzymes e.g., TAILS, PICS, ATOMS, which allow identification of protease cleavage sites and substrates in vivo for the first time. Thereby he established the field of degradomics. The second is levering these techniques to reveal new and often unexpected biological roles for proteases in vivo and their aberrations in disease. The significance of his research has been recognized by many Awards including: 2002 CIHR Researcher of the Year; Tony Pawson Award (2014); and the Proteomass Scientific Society Award (2017). He was elected to the HUPO Executive Council and to Co-Chair HUPO’s Chromosome-Centric Human Proteome Project.
With 258 refereed papers (h-index 85,~26,000 citations, 30 >200), including 27 Nature(1), Science(2), and daughter journal (24) papers, he has mentored 37 PDFs—4 of whom are Full Professors, 3 Associate Professors, and 8 are Assistant Professors.
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